La covid hoy: cómo convivir con el virus que nos derrotó

{"id":1409,"id_simpleblog_post":"1409","id_simpleblog_category":"66","id_simpleblog_post_type":"1","id_simpleblog_author":"0","author":"David Quammen","author_url":"https:\/\/www.penguinlibros.com\/es\/6607-david-quammen","likes":"0","views":"1272","allow_comments":"2","is_featured":"1","access":"a:6:{i:1;b:1;i:2;b:1;i:3;b:1;i:4;b:0;i:5;b:0;i:6;b:0;}","cover":"jpg","featured":"jpg","id_product":"317507,317545","id_category_tematica":"116096,207172,59,116097","id_category_autor":"6607","id_category_editorial":"11355,220742","id_event":"0","active":"1","title":"La covid hoy: c\u00f3mo convivir con el virus que nos derrot\u00f3","meta_title":"La covid hoy: c\u00f3mo convivir con el virus que nos derrot\u00f3","meta_description":"En las siguientes l\u00edneas, David Quammen regresa al momento en que irrumpi\u00f3 la variante \u00f3micron para explicar el apabullante poder de adaptaci\u00f3n de un virus que -nos tememos- siempre estar\u00e1 entre nosotros.","meta_keywords":"Revista LENGUA, David Quammen, Sin aliento, Debate","short_content":"<p>\u00abNo hemos erradicado la poliomielitis, pese a las d\u00e9cadas de intentos. No hemos erradicado el sarampi\u00f3n. Y esos virus no tienen ning\u00fan lugar donde esconderse, excepto dentro de los humanos. Este virus tiene muchas m\u00e1s opciones. Podr\u00edamos eliminarlo de todos los seres humanos de la Tierra (lo cual es improbable) y seguir\u00eda estando all\u00ed, en los ciervos de cola blanca de Iowa o en los visones callejeros del paisaje de Dinamarca\u00bb. En las siguientes l\u00edneas, un texto extra\u00eddo de su libro \u00abSin aliento\u00bb (Debate, 2023), David Quammen, uno de los mejores escritores cient\u00edficos del mundo, regresa al momento en que irrumpi\u00f3 la variante \u00f3micron para explicar el apabullante poder de adaptaci\u00f3n de un virus que -nos tememos- siempre estar\u00e1 entre nosotros.<\/p>","full_content":"","content":"[{\"id\":\"ropvhak\",\"elType\":\"section\",\"isInner\":false,\"settings\":{\"section_layout\":\"\",\"stretch_section\":\"\",\"layout\":\"boxed\",\"content_width\":{\"unit\":\"px\",\"size\":\"\"},\"gap\":\"default\",\"height\":\"default\",\"custom_height\":{\"unit\":\"px\",\"size\":400},\"column_position\":\"middle\",\"content_position\":\"\",\"structure\":\"10\",\"section_background\":\"\",\"background_background\":\"\",\"background_color\":\"\",\"background_color_stop\":{\"unit\":\"%\",\"size\":0},\"background_color_b\":\"\",\"background_color_b_stop\":{\"unit\":\"%\",\"size\":100},\"background_gradient_type\":\"linear\",\"background_gradient_angle\":{\"unit\":\"deg\",\"size\":180},\"background_gradient_position\":\"center 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lo sabe todo acerca de este virus, y <span style=\\\"text-decoration: underline;\\\"><a href=\\\"https:\/\/www.penguinlibros.com\/es\/revista-lengua\/entrevistas\/david-quammen-contagio-federico-kukso\\\" target=\\\"_blank\\\" rel=\\\"noopener\\\">nuestro intento de comprensi\u00f3n sobre \u00e9l no ha hecho m\u00e1s que empezar<\/a><\/span>. Por muy largos que se nos puedan haber antojado los l\u00fagubres meses y a\u00f1os de la pandemia de la COVID-19 \u2014la pandemia hasta ahora\u2014, todav\u00eda es pronto. Apenas hemos empezado a adaptarnos nosotros mismos y adaptar nuestras sociedades para los retos que les aguardan y sus etapas posteriores. Este virus va a permanecer con nosotros para siempre. Estar\u00e1 en los humanos, siempre en alg\u00fan lugar, y estar\u00e1 en algunos de los animales que nos rodean. La regla \u00abNunca digas nunca\u00bb es sensata, pero ning\u00fan experto puede decirnos hoy por hoy c\u00f3mo podr\u00eda erradicarse alguna vez el SARS-CoV-2. No hemos erradicado la poliomielitis, pese a las d\u00e9cadas de intentos. No hemos erradicado el sarampi\u00f3n. Y esos virus no tienen ning\u00fan lugar donde esconderse, excepto dentro de los humanos. Este virus tiene muchas m\u00e1s opciones. Podr\u00edamos eliminarlo de todos los seres humanos de la Tierra (lo cual es improbable) y seguir\u00eda estando all\u00ed, en los ciervos de cola blanca de Iowa o en los visones callejeros del paisaje de Dinamarca.\u00a0<\/p><p>Continuar\u00e1 cambiando. Se adaptar\u00e1 a nuestras adaptaciones. Cuando escribo estas l\u00edneas, la \u00faltima variante, <span style=\\\"text-decoration: underline;\\\"><a href=\\\"https:\/\/espanol.cdc.gov\/coronavirus\/2019-ncov\/variants\/index.html\\\" target=\\\"_blank\\\" rel=\\\"noopener\\\">\u00d3micron<\/a><\/span>, parece un espectacular ejemplo de ello.<\/p>\",\"section_style\":\"\",\"align\":\"\",\"align_tablet\":\"\",\"align_mobile\":\"\",\"text_color\":\"#1a1a1a\",\"typography_typography\":\"custom\",\"typography_font_size\":{\"unit\":\"px\",\"size\":\"18\"},\"typography_font_size_tablet\":{\"unit\":\"px\",\"size\":\"\"},\"typography_font_size_mobile\":{\"unit\":\"px\",\"size\":\"\"},\"typography_font_family\":\"custom\",\"typography_font_family_custom\":\"Fort-Book\",\"typography_font_weight\":\"\",\"typography_text_transform\":\"\",\"typography_font_style\":\"\",\"typography_line_height\":{\"unit\":\"px\",\"size\":\"27\"},\"typography_line_height_tablet\":{\"unit\":\"em\",\"size\":\"\"},\"typography_line_height_mobile\":{\"unit\":\"em\",\"size\":\"\"},\"typography_letter_spacing\":{\"unit\":\"px\",\"size\":\"\"},\"typography_letter_spacing_tablet\":{\"unit\":\"px\",\"size\":\"\"},\"typography_letter_spacing_mobile\":{\"unit\":\"px\",\"size\":\"\"},\"_section_style\":\"\",\"_margin\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"0\",\"bottom\":\"2\",\"left\":\"0\",\"isLinked\":false},\"_margin_tablet\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_margin_mobile\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding_tablet\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding_mobile\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_animation\":\"\",\"animation_duration\":\"\",\"_css_classes\":\"\",\"_section_background\":\"\",\"_background_background\":\"\",\"_background_color\":\"\",\"_background_image\":{\"url\":\"\",\"id\":\"\"},\"_background_position\":\"\",\"_background_attachment\":\"\",\"_background_repeat\":\"\",\"_background_size\":\"\",\"_background_video_link\":\"\",\"_background_video_fallback\":{\"url\":\"\",\"id\":\"\"},\"_border_border\":\"\",\"_border_width\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_border_color\":\"\",\"_border_radius\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_box_shadow_box_shadow_type\":\"\",\"_box_shadow_box_shadow\":{\"horizontal\":0,\"vertical\":0,\"blur\":10,\"spread\":0,\"inset\":\"\",\"color\":\"rgba(0,0,0,0.5)\"},\"_section_responsive\":\"\",\"responsive_description\":\"\",\"hide_desktop\":\"\",\"hide_tablet\":\"\",\"hide_mobile\":\"\"},\"defaultEditSettings\":[],\"widgetType\":\"text-editor\",\"editSettings\":{}}],\"editSettings\":{}}],\"editSettings\":{}},{\"id\":\"5s5si7v\",\"elType\":\"section\",\"isInner\":false,\"settings\":{\"section_layout\":\"\",\"stretch_section\":\"\",\"layout\":\"boxed\",\"content_width\":{\"unit\":\"px\",\"size\":\"\"},\"gap\":\"default\",\"height\":\"default\",\"custom_height\":{\"unit\":\"px\",\"size\":400},\"column_position\":\"middle\",\"content_position\":\"\",\"structure\":\"20\",\"section_background\":\"\",\"background_background\":\"\",\"background_color\":\"\",\"background_color_stop\":{\"unit\":\"%\",\"size\":0},\"background_color_b\":\"\",\"background_color_b_stop\":{\"unit\":\"%\",\"size\":100},\"background_gradient_type\":\"linear\",\"background_gradient_angle\":{\"unit\":\"deg\",\"size\":180},\"background_gradient_position\":\"center 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irrumpi\u00f3 en la escena internacional a finales de noviembre de 2021, cuando unos cient\u00edficos de Sud\u00e1frica informaron de su existencia a la OMS en Ginebra. El jefe del equipo sudafricano era Tulio de Oliveira, el actual director del Centro de Respuesta e Innovaci\u00f3n ante Epidemias de la Universidad de Stellenbosch; tambi\u00e9n es el jefe de la Red para la Vigilancia Gen\u00f3mica del pa\u00eds, adem\u00e1s de profesor en la Universidad de KwaZulu-Natal. A mediados de noviembre, De Oliveira y sus colegas advirtieron un peculiar repunte del n\u00famero de casos en Gauteng, la peque\u00f1a pero densamente poblada provincia a la que pertenecen Johannesburgo y Pretoria. Los cient\u00edficos de la red incrementaron su vigilancia gen\u00f3mica y, desde un laboratorio, el grupo de De Oliveira recibi\u00f3 seis genomas, todos los cuales compart\u00edan una alta incidencia de mutaciones. Eso fue el 23 de noviembre, un martes. Preocupado, el equipo examin\u00f3 otros datos y hall\u00f3 pruebas de la misma cepa, que aumentaba su incidencia en los casos de Gauteng. A la ma\u00f1ana siguiente, 24 de noviembre, como declarar\u00eda posteriormente De Oliveira a <em>The New Yorker,<\/em> \u00abempezamos a ver que podr\u00eda tratarse de una variante s\u00fabitamente nueva\u00bb (ver notas a pie de p\u00e1gina: 1). Alert\u00f3 a la OMS. Un d\u00eda despu\u00e9s, el equipo de De Oliveira recibi\u00f3 un resumen de los resultados de un centenar de muestras m\u00e1s, escogidas aleatoriamente de Gauteng, que se\u00f1alaba que todas esas infecciones correspond\u00edan a la misma variante. Esa ma\u00f1ana inform\u00f3 al ministro de Sanidad y luego al presidente de Sud\u00e1frica, Cyril Ramaphosa. El viernes, con una inusual rapidez, la OMS declar\u00f3 esa nueva variante una Variante Preocupante. Se trataba de otra variante dentro del linaje B, pero muy diferente de todas las dem\u00e1s y, mediante el sistema PANGOLIN, se clasific\u00f3 como B.1.1.529. La OMS, dando un salto hacia delante en el alfabeto griego, la denomin\u00f3 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que hac\u00eda que se activaran las alarmas con \u00d3micron era la presencia de cincuenta y tres mutaciones, cincuenta y tres diferencias con respecto al genoma b\u00e1sico de Wuhan, la mayor\u00eda de ellas en la prote\u00edna de la esp\u00edcula, que provocaban m\u00e1s de treinta cambios en los amino\u00e1cidos de la esp\u00edcula, la mitad de ellos dentro del dominio de uni\u00f3n al receptor. Tambi\u00e9n hab\u00eda dos mutaciones cerca del sitio de escisi\u00f3n de furina. Nadie pod\u00eda discernir con un simple vistazo qu\u00e9 podr\u00edan haber estado haciendo esas mutaciones mientras la variante se propagaba por Gauteng, ni predecir lo que podr\u00edan hacer en otros lugares, pero la noticia se difundi\u00f3 a toda velocidad, incluso m\u00e1s deprisa que la propia \u00d3micron. La ma\u00f1ana del 24 de noviembre en La Jolla, que era la tarde en Edimburgo, Kristian Andersen recibi\u00f3 un mensaje v\u00eda Slack de Andrew Rambaut: \u00abEsta variante es absolutamente demencial\u00bb. Andersen le respondi\u00f3 en cuesti\u00f3n de minutos: \u00ab\u00c9chale un vistazo a la lista de mutaciones: una aut\u00e9ntica locura\u00bb (2).\u00a0<\/p><p>Inmediatamente surgieron dos importantes preguntas con respecto a \u00d3micron, las dos cuestiones que todo el mundo sigue deseando responder, a una escala m\u00e1s amplia, a prop\u00f3sito del propio SARSCoV-2: \u00bfde d\u00f3nde ven\u00eda y qu\u00e9 har\u00eda?\u00a0<\/p>\",\"section_style\":\"\",\"align\":\"\",\"align_tablet\":\"\",\"align_mobile\":\"\",\"text_color\":\"#1a1a1a\",\"typography_typography\":\"custom\",\"typography_font_size\":{\"unit\":\"px\",\"size\":\"18\"},\"typography_font_size_tablet\":{\"unit\":\"px\",\"size\":\"\"},\"typography_font_size_mobile\":{\"unit\":\"px\",\"size\":\"\"},\"typography_font_family\":\"custom\",\"typography_font_family_custom\":\"Fort-Book\",\"typography_font_weight\":\"\",\"typography_text_transform\":\"\",\"typography_font_style\":\"\",\"typography_line_height\":{\"unit\":\"px\",\"size\":\"27\"},\"typography_line_height_tablet\":{\"unit\":\"em\",\"size\":\"\"},\"typography_line_height_mobile\":{\"unit\":\"em\",\"size\":\"\"},\"typography_letter_spacing\":{\"unit\":\"px\",\"size\":\"\"},\"typography_letter_spacing_tablet\":{\"unit\":\"px\",\"size\":\"\"},\"typography_letter_spacing_mobile\":{\"unit\":\"px\",\"size\":\"\"},\"_section_style\":\"\",\"_margin\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"0\",\"bottom\":\"58\",\"left\":\"0\",\"isLinked\":false},\"_margin_tablet\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_margin_mobile\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding_tablet\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding_mobile\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_animation\":\"\",\"animation_duration\":\"\",\"_css_classes\":\"\",\"_section_background\":\"\",\"_background_background\":\"\",\"_background_color\":\"\",\"_background_image\":{\"url\":\"\",\"id\":\"\"},\"_background_position\":\"\",\"_background_attachment\":\"\",\"_background_repeat\":\"\",\"_background_size\":\"\",\"_background_video_link\":\"\",\"_background_video_fallback\":{\"url\":\"\",\"id\":\"\"},\"_border_border\":\"\",\"_border_width\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_border_color\":\"\",\"_border_radius\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_box_shadow_box_shadow_type\":\"\",\"_box_shadow_box_shadow\":{\"horizontal\":0,\"vertical\":0,\"blur\":10,\"spread\":0,\"inset\":\"\",\"color\":\"rgba(0,0,0,0.5)\"},\"_section_responsive\":\"\",\"responsive_description\":\"\",\"hide_desktop\":\"\",\"hide_tablet\":\"\",\"hide_mobile\":\"\"},\"defaultEditSettings\":[],\"widgetType\":\"text-editor\",\"editSettings\":{}},{\"id\":\"lpllcq5\",\"elType\":\"widget\",\"isInner\":false,\"settings\":{\"section_editor\":\"\",\"editor\":\"<p>Apenas hemos empezado a adaptarnos nosotros mismos y adaptar nuestras sociedades para los retos que les aguardan y sus etapas posteriores. Este virus va a permanecer con nosotros para siempre. Estar\u00e1 en los humanos, siempre en alg\u00fan lugar, y estar\u00e1 en algunos de los animales que nos rodean.<\/p>\",\"section_style\":\"\",\"align\":\"\",\"align_tablet\":\"\",\"align_mobile\":\"\",\"text_color\":\"#000000\",\"typography_typography\":\"custom\",\"typography_font_size\":{\"unit\":\"px\",\"size\":\"40\"},\"typography_font_size_tablet\":{\"unit\":\"px\",\"size\":\"\"},\"typography_font_size_mobile\":{\"unit\":\"px\",\"size\":\"24\"},\"typography_font_family\":\"custom\",\"typography_font_family_custom\":\"Vollkorn\",\"typography_font_weight\":\"\",\"typography_text_transform\":\"\",\"typography_font_style\":\"\",\"typography_line_height\":{\"unit\":\"px\",\"size\":\"45\"},\"typography_line_height_tablet\":{\"unit\":\"em\",\"size\":\"\"},\"typography_line_height_mobile\":{\"unit\":\"px\",\"size\":\"30\"},\"typography_letter_spacing\":{\"unit\":\"px\",\"size\":\"\"},\"typography_letter_spacing_tablet\":{\"unit\":\"px\",\"size\":\"\"},\"typography_letter_spacing_mobile\":{\"unit\":\"px\",\"size\":\"\"},\"_section_style\":\"\",\"_margin\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"95\",\"bottom\":\"58\",\"left\":\"95\",\"isLinked\":false},\"_margin_tablet\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"30\",\"bottom\":\"50\",\"left\":\"30\",\"isLinked\":false},\"_margin_mobile\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding_tablet\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding_mobile\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_animation\":\"\",\"animation_duration\":\"\",\"_css_classes\":\"\",\"_section_background\":\"\",\"_background_background\":\"\",\"_background_color\":\"\",\"_background_image\":{\"url\":\"\",\"id\":\"\"},\"_background_position\":\"\",\"_background_attachment\":\"\",\"_background_repeat\":\"\",\"_background_size\":\"\",\"_background_video_link\":\"\",\"_background_video_fallback\":{\"url\":\"\",\"id\":\"\"},\"_border_border\":\"\",\"_border_width\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_border_color\":\"\",\"_border_radius\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_box_shadow_box_shadow_type\":\"\",\"_box_shadow_box_shadow\":{\"horizontal\":0,\"vertical\":0,\"blur\":10,\"spread\":0,\"inset\":\"\",\"color\":\"rgba(0,0,0,0.5)\"},\"_section_responsive\":\"\",\"responsive_description\":\"\",\"hide_desktop\":\"\",\"hide_tablet\":\"\",\"hide_mobile\":\"\"},\"defaultEditSettings\":[],\"widgetType\":\"text-editor\",\"editSettings\":{}},{\"id\":\"3zu9rpr\",\"elType\":\"widget\",\"isInner\":false,\"settings\":{\"section_editor\":\"\",\"editor\":\"<p>La panoplia de mutaciones de \u00d3micron refleja un periodo de evoluci\u00f3n extensiva y activa, ya que las mutaciones no solo se produc\u00edan, sino que se preservaban dentro del linaje, lo cual suger\u00eda que ofrec\u00edan un valor adaptativo (o quiz\u00e1 algunas de ellas, pero no todas, simplemente hab\u00edan tenido suerte). Aquello hab\u00eda sucedido en alg\u00fan contexto no identificado hasta la fecha. De repente, los cambios estaban simplemente ah\u00ed, empaquetados dentro de una \u00fanica cepa de virus que estaba prosperando, tal como se reflejaba en los genomas que el grupo de De Oliveira hab\u00eda visto. En los datos disponibles no hab\u00eda rastro alguno de formas intermedias, que contuvieran solo la mitad de esas mutaciones, pongamos por caso. \u00bfC\u00f3mo explicar la ausencia de intermediarios? Un numeroso grupo de cient\u00edficos, incluido el propio Tulio de Oliveira, abord\u00f3 pronto ese y otros misterios en una extensa publicaci\u00f3n en dos partes en el sitio web Virological. El primer autor de ese grupo era Darren P. Martin, un bioinform\u00e1tico de la Universidad de Ciudad del Cabo.\u00a0<\/p><p>Martin y sus coautores postulaban tres posibles explicaciones para la ausencia de intermediarios a lo largo de la senda hacia \u00d3micron. Puede que el muestreo y la secuenciaci\u00f3n en Sud\u00e1frica hubieran sido demasiado escasos para detectar lo que estaba sucediendo entre la poblaci\u00f3n de pacientes. Seg\u00fan ese escenario, los estadios intermedios estaban ah\u00ed, diseminados entre la multitud, pero la ciencia no los vio. O puede que la variante \u00d3micron evolucionara en un paciente cr\u00f3nicamente infectado y todos los estadios intermedios tuvieran lugar dentro de dicho paciente, en vez de entre un paciente y otro. Seg\u00fan ese escenario, los intermediarios hab\u00edan surgido y exist\u00edan como un enjambre dentro de una persona enferma (o tal vez varias), pero la ciencia no los vio porque de ese paciente no se tomaron muestras de forma reiterada (o no se tomaron de esos distintos pacientes), y la variante surgi\u00f3 de pleno derecho. Los pacientes inmunodeficientes tienen m\u00e1s probabilidades de sufrir infecciones prolongadas con el SARS-CoV-2 y, como me record\u00f3 Penny Moore, Sud\u00e1frica tiene un n\u00famero elevado de individuos inmunodeficientes por estar viviendo con el 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tercera posibilidad se remontaba a los ciclos selv\u00e1ticos y la fauna salvaje. Puede que \u00d3micron derivara de un acontecimiento zoon\u00f3tico inverso: transmisi\u00f3n humana a un animal no humano, seguida por un periodo de evoluci\u00f3n en la poblaci\u00f3n de animales, seguida a continuaci\u00f3n por un nuevo derrame a los humanos. Un paradigma para este escenario era la variante Cluster 5 que hab\u00eda saltado de los visones a las personas en Dinamarca un a\u00f1o antes. Lo que cambiar\u00eda ser\u00eda que \u00d3micron, a diferencia de Cluster 5, resultaba de combinar mutaciones que lo tornaban extremadamente transmisible entre humanos. Los estadios intermedios podr\u00edan estar ah\u00ed, en los bosques, pero la ciencia no los vio porque la ciencia no estaba tomando muestras de animales salvajes (\u00bfleones, leopardos, zorrillas comunes?) en Sud\u00e1frica. \u00abHoy por hoy no existen pruebas directas que respalden o refuten ninguna de estas hip\u00f3tesis sobre el origen de \u00d3micron \u2014aseveraba el grupo de Martin\u2014, pero conforme se recopilen nuevos datos, podr\u00e1 definirse con m\u00e1s precisi\u00f3n su origen\u00bb (3). O no.\u00a0<\/p><p>Las numerosas innovaciones incorporadas en \u00d3micron \u2014y, en particular, trece cambios en los amino\u00e1cidos de la prote\u00edna de la esp\u00edcula que no han aparecido en otras variantes del SARS-CoV-2\u2014 suger\u00edan a Martin y a sus coautores que la selecci\u00f3n natural darwiniana favorec\u00eda las mutaciones individual o colectivamente, toda vez que aumentaba la capacidad del virus para replicarse, para transmitirse o para esquivar las defensas inmunitarias. (Resulta importante recordar que determinadas mutaciones, con un efecto individualmente neutral o incluso negativo, pueden transmitirse por puro azar, pero probablemente no cincuenta y tres de ellas en un mismo linaje). \u00bfCu\u00e1nto mejor se transmitir\u00eda la variante? \u00bfCon cu\u00e1nta efectividad esquivar\u00eda las defensas inmunitarias, incluidas las proporcionadas por las vacunas y las dosis de refuerzo? Esas preguntas tambi\u00e9n se responder\u00e1n mejor \u00abconforme se re\u00fanan nuevos datos\u00bb. La situaci\u00f3n es fluida. 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yo.<\/p>\",\"section_style\":\"\",\"align\":\"\",\"align_tablet\":\"\",\"align_mobile\":\"\",\"text_color\":\"#1a1a1a\",\"typography_typography\":\"custom\",\"typography_font_size\":{\"unit\":\"px\",\"size\":\"18\"},\"typography_font_size_tablet\":{\"unit\":\"px\",\"size\":\"\"},\"typography_font_size_mobile\":{\"unit\":\"px\",\"size\":\"\"},\"typography_font_family\":\"custom\",\"typography_font_family_custom\":\"Fort-Book\",\"typography_font_weight\":\"\",\"typography_text_transform\":\"\",\"typography_font_style\":\"\",\"typography_line_height\":{\"unit\":\"px\",\"size\":\"27\"},\"typography_line_height_tablet\":{\"unit\":\"em\",\"size\":\"\"},\"typography_line_height_mobile\":{\"unit\":\"em\",\"size\":\"\"},\"typography_letter_spacing\":{\"unit\":\"px\",\"size\":\"\"},\"typography_letter_spacing_tablet\":{\"unit\":\"px\",\"size\":\"\"},\"typography_letter_spacing_mobile\":{\"unit\":\"px\",\"size\":\"\"},\"_section_style\":\"\",\"_margin\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"0\",\"bottom\":\"58\",\"left\":\"0\",\"isLinked\":false},\"_margin_tablet\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_margin_mobile\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding_tablet\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding_mobile\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_animation\":\"\",\"animation_duration\":\"\",\"_css_classes\":\"\",\"_section_background\":\"\",\"_background_background\":\"\",\"_background_color\":\"\",\"_background_image\":{\"url\":\"\",\"id\":\"\"},\"_background_position\":\"\",\"_background_attachment\":\"\",\"_background_repeat\":\"\",\"_background_size\":\"\",\"_background_video_link\":\"\",\"_background_video_fallback\":{\"url\":\"\",\"id\":\"\"},\"_border_border\":\"\",\"_border_width\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_border_color\":\"\",\"_border_radius\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_box_shadow_box_shadow_type\":\"\",\"_box_shadow_box_shadow\":{\"horizontal\":0,\"vertical\":0,\"blur\":10,\"spread\":0,\"inset\":\"\",\"color\":\"rgba(0,0,0,0.5)\"},\"_section_responsive\":\"\",\"responsive_description\":\"\",\"hide_desktop\":\"\",\"hide_tablet\":\"\",\"hide_mobile\":\"\"},\"defaultEditSettings\":[],\"widgetType\":\"text-editor\",\"editSettings\":{}},{\"id\":\"widh44v\",\"elType\":\"widget\",\"isInner\":false,\"settings\":{\"section_editor\":\"\",\"editor\":\"<p>La panoplia de mutaciones de \u00d3micron refleja un periodo de evoluci\u00f3n extensiva y activa, ya que las mutaciones no solo se produc\u00edan, sino que se preservaban dentro del linaje, lo cual suger\u00eda que ofrec\u00edan un valor adaptativo (o quiz\u00e1 algunas de ellas, pero no todas, simplemente hab\u00edan tenido suerte).<\/p>\",\"section_style\":\"\",\"align\":\"\",\"align_tablet\":\"\",\"align_mobile\":\"\",\"text_color\":\"#000000\",\"typography_typography\":\"custom\",\"typography_font_size\":{\"unit\":\"px\",\"size\":\"40\"},\"typography_font_size_tablet\":{\"unit\":\"px\",\"size\":\"\"},\"typography_font_size_mobile\":{\"unit\":\"px\",\"size\":\"24\"},\"typography_font_family\":\"custom\",\"typography_font_family_custom\":\"Vollkorn\",\"typography_font_weight\":\"\",\"typography_text_transform\":\"\",\"typography_font_style\":\"\",\"typography_line_height\":{\"unit\":\"px\",\"size\":\"45\"},\"typography_line_height_tablet\":{\"unit\":\"em\",\"size\":\"\"},\"typography_line_height_mobile\":{\"unit\":\"px\",\"size\":\"30\"},\"typography_letter_spacing\":{\"unit\":\"px\",\"size\":\"\"},\"typography_letter_spacing_tablet\":{\"unit\":\"px\",\"size\":\"\"},\"typography_letter_spacing_mobile\":{\"unit\":\"px\",\"size\":\"\"},\"_section_style\":\"\",\"_margin\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"95\",\"bottom\":\"58\",\"left\":\"95\",\"isLinked\":false},\"_margin_tablet\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"30\",\"bottom\":\"50\",\"left\":\"30\",\"isLinked\":false},\"_margin_mobile\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding_tablet\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding_mobile\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_animation\":\"\",\"animation_duration\":\"\",\"_css_classes\":\"\",\"_section_background\":\"\",\"_background_background\":\"\",\"_background_color\":\"\",\"_background_image\":{\"url\":\"\",\"id\":\"\"},\"_background_position\":\"\",\"_background_attachment\":\"\",\"_background_repeat\":\"\",\"_background_size\":\"\",\"_background_video_link\":\"\",\"_background_video_fallback\":{\"url\":\"\",\"id\":\"\"},\"_border_border\":\"\",\"_border_width\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_border_color\":\"\",\"_border_radius\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_box_shadow_box_shadow_type\":\"\",\"_box_shadow_box_shadow\":{\"horizontal\":0,\"vertical\":0,\"blur\":10,\"spread\":0,\"inset\":\"\",\"color\":\"rgba(0,0,0,0.5)\"},\"_section_responsive\":\"\",\"responsive_description\":\"\",\"hide_desktop\":\"\",\"hide_tablet\":\"\",\"hide_mobile\":\"\"},\"defaultEditSettings\":[],\"widgetType\":\"text-editor\",\"editSettings\":{}},{\"id\":\"lczqy08\",\"elType\":\"widget\",\"isInner\":false,\"settings\":{\"section_editor\":\"\",\"editor\":\"<p>Los coautores abordaban asimismo otra intrigante incertidumbre a la que acabo de aludir: \u00bffavoreci\u00f3 la selecci\u00f3n evolutiva todos los cambios significativos de \u00d3micron de manera individual, amino\u00e1cido a amino\u00e1cido, o los favoreci\u00f3 en su conjunto, por su efecto combinado, su compleja interacci\u00f3n y su balance final colectivo? La segunda de estas propuestas, como se\u00f1alaban Martin y sus coautores, tiene un nombre sofisticado en gen\u00e9tica: \u00abepistasis positiva\u00bb. Este concepto es sencillo (solo los detalles son complejos). La epistasis se refiere a los efectos interactivos de los genes en diferentes partes del genoma, enfrent\u00e1ndose entre s\u00ed o armonizando, al igual que los instrumentos en distintas partes de una orquesta. Una mutaci\u00f3n inclinada a ejercer un impacto neutral o incluso negativo individualmente puede desempe\u00f1ar una funci\u00f3n beneficiosa cuando ese gen interact\u00faa con otros. Adem\u00e1s, el efecto de un gen mutado puede depender de la presencia o ausencia de mutaciones en otros genes. En el contexto de \u00d3micron, la epistasis positiva se traduce en que las numerosas mutaciones est\u00e1n potenciando mutuamente su valor adaptativo. Esta variante, con su gran n\u00famero de mutaciones, puede ser una criatura que se est\u00e1 volviendo m\u00e1s temible en virtud de las grandes dificultades de la epistasis.\u00a0<\/p><p>Kristian Andersen cuenta en su laboratorio con una investigadora posdoctoral que lo expresaba m\u00e1s gr\u00e1ficamente cuando dec\u00eda que \u00abel jodido circo del sol epist\u00e1tico de este virus resulta desconcertante\u00bb (4).<\/p>\",\"section_style\":\"\",\"align\":\"\",\"align_tablet\":\"\",\"align_mobile\":\"\",\"text_color\":\"#1a1a1a\",\"typography_typography\":\"custom\",\"typography_font_size\":{\"unit\":\"px\",\"size\":\"18\"},\"typography_font_size_tablet\":{\"unit\":\"px\",\"size\":\"\"},\"typography_font_size_mobile\":{\"unit\":\"px\",\"size\":\"\"},\"typography_font_family\":\"custom\",\"typography_font_family_custom\":\"Fort-Book\",\"typography_font_weight\":\"\",\"typography_text_transform\":\"\",\"typography_font_style\":\"\",\"typography_line_height\":{\"unit\":\"px\",\"size\":\"27\"},\"typography_line_height_tablet\":{\"unit\":\"em\",\"size\":\"\"},\"typography_line_height_mobile\":{\"unit\":\"em\",\"size\":\"\"},\"typography_letter_spacing\":{\"unit\":\"px\",\"size\":\"\"},\"typography_letter_spacing_tablet\":{\"unit\":\"px\",\"size\":\"\"},\"typography_letter_spacing_mobile\":{\"unit\":\"px\",\"size\":\"\"},\"_section_style\":\"\",\"_margin\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"0\",\"bottom\":\"40\",\"left\":\"0\",\"isLinked\":false},\"_margin_tablet\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_margin_mobile\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding_tablet\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding_mobile\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_animation\":\"\",\"animation_duration\":\"\",\"_css_classes\":\"\",\"_section_background\":\"\",\"_background_background\":\"\",\"_background_color\":\"\",\"_background_image\":{\"url\":\"\",\"id\":\"\"},\"_background_position\":\"\",\"_background_attachment\":\"\",\"_background_repeat\":\"\",\"_background_size\":\"\",\"_background_video_link\":\"\",\"_background_video_fallback\":{\"url\":\"\",\"id\":\"\"},\"_border_border\":\"\",\"_border_width\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_border_color\":\"\",\"_border_radius\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_box_shadow_box_shadow_type\":\"\",\"_box_shadow_box_shadow\":{\"horizontal\":0,\"vertical\":0,\"blur\":10,\"spread\":0,\"inset\":\"\",\"color\":\"rgba(0,0,0,0.5)\"},\"_section_responsive\":\"\",\"responsive_description\":\"\",\"hide_desktop\":\"\",\"hide_tablet\":\"\",\"hide_mobile\":\"\"},\"defaultEditSettings\":[],\"widgetType\":\"text-editor\",\"editSettings\":{}},{\"id\":\"xn5dwa6\",\"elType\":\"widget\",\"isInner\":false,\"settings\":{\"section_editor\":\"\",\"editor\":\"<p><strong>Notas:<\/strong><\/p><p>1) <span style=\\\"text-decoration: underline;\\\"><a href=\\\"https:\/\/www.newyorker.com\/news\/q-and-a\/how-south-african-researchers-identified-the-omicron-variant-of-covid\\\" target=\\\"_blank\\\" rel=\\\"noopener\\\">Isaac Chotiner, <em>The New Yorker<\/em>, 30\/11\/21<\/a><\/span>.<\/p><p>2)\u2002<span style=\\\"text-decoration: underline;\\\"><a href=\\\"https:\/\/www.science.org\/content\/article\/patience-crucial-why-we-won-t-know-weeks-how-dangerous-omicron\\\" target=\\\"_blank\\\" rel=\\\"noopener\\\">Kai Kupferschmidt, <em>Science<\/em>, 27\/11\/21<\/a><\/span>.<\/p><p>3) <span style=\\\"text-decoration: underline;\\\"><a href=\\\"https:\/\/virological.org\/t\/selection-analysis-identifies-significant-mutational-changes-in-omicron-that-are-likely-to-influence-both-antibody-neutralization-and-spike-function-part-1-of-2\/771\\\" target=\\\"_blank\\\" rel=\\\"noopener\\\">Publicaci\u00f3n de Martin <em>et al<\/em>. en Virological.org, 5\/12\/21<\/a><\/span>.<\/p><p>4) Citado en Twitter por Kristian Andersen, 5\/12\/21; utilizado aqu\u00ed con permiso de Edyth Parker.<\/p>\",\"section_style\":\"\",\"align\":\"\",\"align_tablet\":\"\",\"align_mobile\":\"\",\"text_color\":\"#1a1a1a\",\"typography_typography\":\"custom\",\"typography_font_size\":{\"unit\":\"px\",\"size\":\"18\"},\"typography_font_size_tablet\":{\"unit\":\"px\",\"size\":\"\"},\"typography_font_size_mobile\":{\"unit\":\"px\",\"size\":\"\"},\"typography_font_family\":\"custom\",\"typography_font_family_custom\":\"Fort-Book\",\"typography_font_weight\":\"\",\"typography_text_transform\":\"\",\"typography_font_style\":\"\",\"typography_line_height\":{\"unit\":\"px\",\"size\":\"27\"},\"typography_line_height_tablet\":{\"unit\":\"em\",\"size\":\"\"},\"typography_line_height_mobile\":{\"unit\":\"em\",\"size\":\"\"},\"typography_letter_spacing\":{\"unit\":\"px\",\"size\":\"\"},\"typography_letter_spacing_tablet\":{\"unit\":\"px\",\"size\":\"\"},\"typography_letter_spacing_mobile\":{\"unit\":\"px\",\"size\":\"\"},\"_section_style\":\"\",\"_margin\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"0\",\"bottom\":\"40\",\"left\":\"0\",\"isLinked\":false},\"_margin_tablet\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_margin_mobile\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding_tablet\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding_mobile\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_animation\":\"\",\"animation_duration\":\"\",\"_css_classes\":\"\",\"_section_background\":\"\",\"_background_background\":\"\",\"_background_color\":\"\",\"_background_image\":{\"url\":\"\",\"id\":\"\"},\"_background_position\":\"\",\"_background_attachment\":\"\",\"_background_repeat\":\"\",\"_background_size\":\"\",\"_background_video_link\":\"\",\"_background_video_fallback\":{\"url\":\"\",\"id\":\"\"},\"_border_border\":\"\",\"_border_width\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_border_color\":\"\",\"_border_radius\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_box_shadow_box_shadow_type\":\"\",\"_box_shadow_box_shadow\":{\"horizontal\":0,\"vertical\":0,\"blur\":10,\"spread\":0,\"inset\":\"\",\"color\":\"rgba(0,0,0,0.5)\"},\"_section_responsive\":\"\",\"responsive_description\":\"\",\"hide_desktop\":\"\",\"hide_tablet\":\"\",\"hide_mobile\":\"\"},\"defaultEditSettings\":[],\"widgetType\":\"text-editor\",\"editSettings\":{}},{\"id\":\"k0hq5n8\",\"elType\":\"widget\",\"isInner\":false,\"settings\":{\"section_editor\":\"\",\"editor\":\"<p class=\\\"MsoNormal\\\"><strong>OTROS\u00a0CONTENIDOS DE INTER\u00c9S:<\/strong><\/p><p><span style=\\\"text-decoration: underline;\\\"><a href=\\\"https:\/\/www.penguinlibros.com\/es\/revista-lengua\/entrevistas\/david-quammen-contagio-federico-kukso\\\" target=\\\"_blank\\\" rel=\\\"noopener\\\">David Quammen: el hombre que escuch\u00f3 llegar a la covid-19<\/a><\/span><\/p><p><span style=\\\"text-decoration: underline;\\\"><a href=\\\"https:\/\/www.penguinlibros.com\/es\/revista-lengua\/no-ficcion\/walter-isaacson-el-codigo-de-la-vida\\\" target=\\\"_blank\\\" rel=\\\"noopener\\\">Walter Isaacson: gen\u00e9tica, covid y el futuro de la humanidad<\/a><\/span><\/p><p><span style=\\\"text-decoration: underline;\\\"><a href=\\\"https:\/\/www.penguinlibros.com\/es\/revista-lengua\/entrevistas\/yuval-noah-harari-sapiens-moises-naim-hay-festival\\\" target=\\\"_blank\\\" rel=\\\"noopener\\\">Yuval Noah Harari: \u00abLa inteligencia artificial es una amenaza a la existencia humana\u00bb<\/a><\/span><\/p><p><span style=\\\"text-decoration: underline;\\\"><a href=\\\"https:\/\/www.penguinlibros.com\/es\/revista-lengua\/no-ficcion\/javier-cercas-paradojas-pandemia\\\" target=\\\"_blank\\\" rel=\\\"noopener\\\">Javier Cercas: paradojas de la pandemia<\/a><\/span><\/p><p><\/p><p><\/p><p><\/p>\",\"section_style\":\"\",\"align\":\"\",\"align_tablet\":\"\",\"align_mobile\":\"\",\"text_color\":\"#1a1a1a\",\"typography_typography\":\"custom\",\"typography_font_size\":{\"unit\":\"px\",\"size\":\"18\"},\"typography_font_size_tablet\":{\"unit\":\"px\",\"size\":\"\"},\"typography_font_size_mobile\":{\"unit\":\"px\",\"size\":\"\"},\"typography_font_family\":\"custom\",\"typography_font_family_custom\":\"Fort-Book\",\"typography_font_weight\":\"\",\"typography_text_transform\":\"\",\"typography_font_style\":\"\",\"typography_line_height\":{\"unit\":\"px\",\"size\":\"27\"},\"typography_line_height_tablet\":{\"unit\":\"em\",\"size\":\"\"},\"typography_line_height_mobile\":{\"unit\":\"em\",\"size\":\"\"},\"typography_letter_spacing\":{\"unit\":\"px\",\"size\":\"\"},\"typography_letter_spacing_tablet\":{\"unit\":\"px\",\"size\":\"\"},\"typography_letter_spacing_mobile\":{\"unit\":\"px\",\"size\":\"\"},\"_section_style\":\"\",\"_margin\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"0\",\"bottom\":\"58\",\"left\":\"0\",\"isLinked\":false},\"_margin_tablet\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_margin_mobile\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding\":{\"unit\":\"px\",\"top\":\"20\",\"right\":\"20\",\"bottom\":\"20\",\"left\":\"20\",\"isLinked\":true},\"_padding_tablet\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_padding_mobile\":{\"unit\":\"px\",\"top\":\"\",\"right\":\"\",\"bottom\":\"\",\"left\":\"\",\"isLinked\":true},\"_animation\":\"\",\"animation_duration\":\"\",\"_css_classes\":\"\",\"_section_background\":\"\",\"_background_background\":\"\",\"_background_color\":\"\",\"_background_image\":{\"url\":\"\",\"id\":\"\"},\"_background_position\":\"\",\"_background_attachment\":\"\",\"_background_repeat\":\"\",\"_background_size\":\"\",\"_background_video_link\":\"\",\"_background_video_fallback\":{\"url\":\"\",\"id\":\"\"},\"_border_border\":\"solid\",\"_border_width\":{\"unit\":\"px\",\"top\":\"1\",\"right\":\"1\",\"bottom\":\"1\",\"left\":\"1\",\"isLinked\":true},\"_border_color\":\"\",\"_border_radius\":{\"unit\":\"px\",\"top\":\"20\",\"right\":\"20\",\"bottom\":\"20\",\"left\":\"20\",\"isLinked\":true},\"_box_shadow_box_shadow_type\":\"\",\"_box_shadow_box_shadow\":{\"horizontal\":0,\"vertical\":0,\"blur\":10,\"spread\":0,\"inset\":\"\",\"color\":\"rgba(0,0,0,0.5)\"},\"_section_responsive\":\"\",\"responsive_description\":\"\",\"hide_desktop\":\"\",\"hide_tablet\":\"\",\"hide_mobile\":\"\"},\"defaultEditSettings\":[],\"widgetType\":\"text-editor\",\"editSettings\":{}}],\"editSettings\":{}}],\"editSettings\":{}},{\"id\":\"hkwh5ij\",\"elType\":\"section\",\"isInner\":false,\"settings\":{\"section_layout\":\"\",\"stretch_section\":\"section-stretched\",\"layout\":\"full_width\",\"content_width\":{\"unit\":\"px\",\"size\":\"\"},\"gap\":\"default\",\"height\":\"default\",\"custom_height\":{\"unit\":\"px\",\"size\":400},\"column_position\":\"middle\",\"content_position\":\"\",\"structure\":\"10\",\"section_background\":\"\",\"background_background\":\"\",\"background_color\":\"\",\"background_color_stop\":{\"unit\":\"%\",\"size\":0},\"background_color_b\":\"\",\"background_color_b_stop\":{\"unit\":\"%\",\"size\":100},\"background_gradient_type\":\"linear\",\"background_gradient_angle\":{\"unit\":\"deg\",\"size\":180},\"background_gradient_position\":\"center 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